Hey guys!
I've been working on this tutorial to allow communications from a WinForms to a TinyDuino over serial. This project is mostly event based in Visual studio but the concepts are pretty universal in C# applications, meaning you could adapt the code to work from unity or other game engines to make some pretty cool peripherals!
http://www.instructables.com/id/Communication-From-a-WinForms-to-a-TinyDuino/Feel free to ask any questions if you need help or whatnot!