I'm just thinking out loud here...
A development system that uses cable interconnects that comes to mind is Seeedstudio's Xadow which has a 12 line interconnect cable. Seeedstudio's Film (discontinued) used 20 lines with each component/shield called a Frame. The connector used on the Tinyduino is 2x16 pin connector for 32 signal lines.
A configuration with two 0.3 mm pitch 33 pin FFP/FFC flat cable connectors (such as the YLL-U or YLL-D SERIES), one on each side of the board would require running 32 lines (don't need the 33rd) across the board. This probably would require at least one more board layer. What about electrical noise because who knows what kind of havoc that configuration could cause on the lines with components above/below them? Perhaps 1 layer of shielding if there are components only on top, or 2 layer of shielding if there are components only on top and bottom. That's pretty expensive. Could the shielding be eliminated? Perhaps, but stacking order may be effected since some shields may be noisier than others.
Please pardon the stick figure diagrams :-P
- o - mounting holes
- [ - FFP/FFC Connector
- ==== - Flat cable
- ......... - Lines
Top View------------- ------------- -------------
| o o | | o o | | o o |
| [.........[ |====| [.........[ |====| [.........[ |
| o o | | o o | | o o |
------------- ------------- -------------
Side View of Layers for new Tinyduino boards
:-/ I don't know... seems risky
--------------- Circuits
--------------- Lines
--------------- Circuits
2 layers of shielding to protect against other tiny shield noise?
Components only on top
--------------- Circuits
--------------- Shielding
--------------- Lines
--------------- Shielding
Components only on bottom
--------------- Shielding
--------------- Lines
--------------- Shielding
--------------- Circuits
Components on top and bottom with 2 layers of shielding. Probably safest... expensive.
--------------- Circuits
--------------- Shielding
--------------- Lines
--------------- Shielding
--------------- Circuits
These suggestions make the PCBs thicker... I am not sure that is totally desirable but it may be necessary for this configuration.