Technically, you should be able to connect a Pi Zero to a Tinyscreen+ through a simple serial connection. There are many tutorials online for this. You could then treat the Tinscreen+ as a video driver output device and let the Pi Zero handle project processing and content.

We do something similar. Our core product runs a standard pi3 and it is connected to the tinyscreen+ through a serial connection. We have got a small menu system to setup the ip address on the pi etc. And we show some stats. But we don't use it as a display driver (or something like that), but that is because we run a linux version with out any desktop etc. So we have got a small program that is running as a daemon on the pi. It communicates with the Tinyscreen+ module.

I am a c# programmer by trade, so i am working hard on brushing up my c++ skills. I wrote a small gui lib for this project, i am thinking about putting it up on GitHub, but i first need to clean up the code 

Regards,

Per